Links among poor sleep, high blood pressure, gut microbiome discovered: Study shows potential negative effects of disrupted sleep – Science Daily

You can Lower Your High Blood Pressure with Proven Natural Remedies

Science News from research organizations 1

2

Links among poor sleep, high blood pressure, gut microbiome discovered

Study shows potential negative effects of disrupted sleep

Date:
September 2, 2020
Source:
University of Illinois at Chicago
Summary:
Researchers have found associations among disrupted sleep, elevated blood pressure and changes in the gut microbiome. The research aimed to determine whether a 28-day period of disrupted sleep changed the microbiota in rats. The researchers also sought to identify biological features associated with undesirable arterial blood pressure changes.
Share:

FULL STORY

In the first study of its kind, University of Illinois Chicago researchers have found associations among disrupted sleep, elevated blood pressure and changes in the gut microbiome.

advertisement

The research aimed to determine whether a 28-day period of disrupted sleep changed the microbiota in rats. The gut microbiota refers to the collection of microorganisms living in the intestines. The researchers also sought to identify biological features associated with undesirable arterial blood pressure changes.

The results were published in Physiological Genomics.

Using rats, the researcher disrupted their sleep periods. Rats are nocturnal, so the experiments were designed to interfere with their daytime sleep periods.

Telemetry transmitters measured the rats' brain activity, blood pressure and heart rate. Fecal matter also was analyzed to examine changes in the microbial content.

The research idea was generated by several of the paper's authors who are or have been health care providers with night-shift schedules.

"When rats had an abnormal sleep schedule, an increase in blood pressure developed — the blood pressure remained elevated even when they could return to normal sleep. This suggests that dysfunctional sleep impairs the body for a sustained period," Maki said.

Undesirable changes also were found in the gut microbiome — the genetic material of all bacteria living in the colon.

Contrary to her initial hypothesis, Maki found that the gut microbiome changes did not happen immediately, but instead took a week to show unfavorable responses such as an imbalance among different types of bacteria including an increase in microbes associated with inflammation.

"When the sleep disruption stopped, everything did not come back to normal immediately," Maki said. "This research shows a very complex system with the presence of multiple pathological factors."

This was initial research, and studies will continue to examine pathways involving the gut microbiome and metabolites produced by gut bacteria. The researchers will see exactly how sleep characteristics are changed and how long blood pressure and gut microbiome alterations persist. Researchers will then determine how this information translates to humans.

"We hope to find an intervention that can help people who are at risk for cardiovascular disease because of their work and sleep schedules. People will always have responsibilities that interrupt their sleep. We want to be able to reduce their risk by targeting the microbiome with new therapies or dietary changes," Fink said.

make a difference: sponsored opportunity

Story Source:

Materials provided by University of Illinois at Chicago. Note: Content may be edited for style and length.

Journal Reference:

  1. Katherine A. Maki, Larisa A. Burke, Michael W. Calik, Miki Watanabe-Chailland, Dagmar Sweeney, Lindsey E. Romick-Rosendale, Stefan J. Green, Anne M. Fink. Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats. Physiological Genomics, 2020; 52 (7): 280 DOI: 10.1152/physiolgenomics.00039.2020

Cite This Page:

University of Illinois at Chicago. "Links among poor sleep, high blood pressure, gut microbiome discovered: Study shows potential negative effects of disrupted sleep." ScienceDaily. ScienceDaily, 2 September 2020. <www.sciencedaily.com/releases/2020/09/200902182439.htm>. University of Illinois at Chicago. (2020, September 2). Links among poor sleep, high blood pressure, gut microbiome discovered: Study shows potential negative effects of disrupted sleep. ScienceDaily. Retrieved September 2, 2020 from www.sciencedaily.com/releases/2020/09/200902182439.htm University of Illinois at Chicago. "Links among poor sleep, high blood pressure, gut microbiome discovered: Study shows potential negative effects of disrupted sleep." ScienceDaily. www.sciencedaily.com/releases/2020/09/200902182439.htm (accessed September 2, 2020).
advertisement 1

2

3

4

5

RELATED STORIES

Gut Bacteria May Be Linked to High Blood Pressure and Depression

Sep. 5, 2019 — A study of human gut bacteria — known as the gut microbiome — suggests that high blood pressure with depression may be a completely different disease than high blood pressure without depression. …

Untreated Sleep Apnea Shown to Raise Metabolic and Cardiovascular Stress

Aug. 31, 2017 — Sleep apnea, left untreated for even a few days, can increase blood sugar and fat levels, stress hormones and blood pressure, according to a new study of sleeping subjects. This research adds further …

Lack of Sleep Increases a Child's Risk for Emotional Disorders Later

July 22, 2016 — Children who experience inadequate or disrupted sleep are more likely to develop depression and anxiety disorders later in life according to recent research. The study seeks to determine the precise …

With a Broken Circadian Clock, Even a Low-Salt Diet Can Raise Resting Blood Pressure, Promote Disease

Feb. 1, 2016 — In the face of a disrupted circadian rhythm, a low-salt diet and a hormone known to constrict blood vessels have the same unhealthy result: elevated resting blood pressure and vascular disease, … FROM AROUND THE WEB Below are relevant articles that may interest you. ScienceDaily shares links with scholarly publications in the TrendMD network and earns revenue from third-party advertisers, where indicated. Print Email Share advertisement 1

2

3

4

5

Most Popular this week HEALTH & MEDICINE

Stroke Warning Signs Often Occur Hours Or Days Before Attack
The Six Strains of SARS-CoV-2
COVID-19 False Negative Test Results If Used Too Early

MIND & BRAIN

Links Among Poor Sleep, High Blood Pressure, Gut Microbiome Discovered: Study Shows Potential Negative Effects Of Disrupted Sleep - Science DailyGot Fatigue? Study Further Pinpoints Brain Regions That May Control It
(c) (c) Jorm S / Adobe - Links Among Poor Sleep, High Blood Pressure, Gut Microbiome Discovered: Study Shows Potential Negative Effects Of Disrupted Sleep - Science DailyResearchers Discover a Specific Brain Circuit Damaged by Social Isolation During Childhood
Loss of Smell and Taste Validated as COVID-19 Symptoms in Patients With High Recovery Rate

LIVING & WELL

Boy or Girl? It's in the Father's Genes
(c) (c) fizkes / Adobe - Links Among Poor Sleep, High Blood Pressure, Gut Microbiome Discovered: Study Shows Potential Negative Effects Of Disrupted Sleep - Science DailyWhen You're Smiling, the Whole World Really Does Smile With You
Polymers Prevent Potentially Hazardous Mist During Dentist Visit

advertisement